Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
Tesa M. Severson (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Yongsoo Kim (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Stacey E.P. Joosten (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Karianne Schuurman (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Petra Van Der Groep (University Medical Center Utrecht)
Cathy B. Moelans (University Medical Center Utrecht)
Natalie D. Ter Hoeve (University Medical Center Utrecht)
Quirine F. Manson (University Medical Center Utrecht)
John W. Martens (Dutch Breast Cancer Research Group, Erasmus MC, Cancer Genomics Centre)
Lodewyk Wessels (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis, Cancer Genomics Centre, TU Delft - Pattern Recognition and Bioinformatics)
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Abstract
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.