Characterizing steroid hormone receptor chromatin binding landscapes in male and female breast cancer
Tesa M. Severson (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Yongsoo Kim (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Stacey E.P. Joosten (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Karianne Schuurman (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
Petra Van Der Groep ( University Medical Centre Utrecht)
Cathy B. Moelans ( University Medical Centre Utrecht)
Natalie D. Ter Hoeve ( University Medical Centre Utrecht)
Quirine F. Manson ( University Medical Centre Utrecht)
John W. Martens ( University Medical Centre Utrecht, Erasmus MC, Dutch Breast Cancer Research Group)
Lodewyk Wessels (TU Delft - Electrical Engineering, Mathematics and Computer Science, University Medical Centre Utrecht, Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)
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Abstract
Male breast cancer (MBC) is rare and largely hormonally driven. Here, the authors examine the action of steroid hormone receptors in male and female breast cancers and find gender selective hormone receptor action that associates with the survival of MBC patients.