What makes long DNA short?

Modulation of DNA structure by Dps protein: cooperating & reorganizing

Doctoral thesis (2016)

Authors

N. Vtyurina BN/Elio Abbondanzieri Lab
Research Group
BN/Elio Abbondanzieri Lab
Copyright: © 2016 N. Vtyurina
DOI
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https://doi.org/10.4233/uuid:14080918-3a6e-48ad-8c47-906538f689ac
Hysteresis Single-molecule DNA condensation Dps protein Cooperativity Reorganization Ising model
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Published Date

2016

Language

English

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Research Group

BN/Elio Abbondanzieri Lab

Abstract

Each confined cell created by nature and containing DNA molecule falls into the category of “alive organism”. All information about this organism is encoded in DNA molecule in genes, except of fate only. Along with the DNA molecule that represents genetic carrier, the organism neither the genome could function without proteins. Proteins are the building blocks from which cells are assembled and capable of activating or disabling particular genes playing a crucial role in DNA replication, repair and protection. In order to understand the function of each singular protein and its role in the overall cellular metabolism, we need to characterize it from different perspectives. Without this knowledge, we do not possess a complete picture of the vitally important processes in the cell and might be losing a very promising pipeline for a treatment of many diseases.