Anything but Conventional Chromatography Approaches in Bioseparation

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Anything but Conventional Chromatography Approaches in Bioseparation

Journal Article (2020)

Author(s)

Ana Cecília Afonso Roque (NOVA School of Science and Technology, Caparica)

Ana Sofia Pina (NOVA School of Science and Technology, Caparica)

Ana Margarida Azevedo (Universidade Técnica de Lisboa)

Raquel Aires-Barros (Universidade Técnica de Lisboa)

Alois Jungbauer (BOKU-University of Natural Resources and Life Sciences)

Gianluca Di Profio (Istituto per i sistemi agricoli e forestali del mediterraneo, Consiglio Nazionale delle Ricerche)

Jerry Y.Y. Heng (Imperial College London)

Jonathan Haigh (FUJIFILM Diosynth Biotechnologies UK Limited, Billingham)

Marcel Ottens (TU Delft - BT/Bioprocess Engineering)

Research Group

BT/Bioprocess Engineering

Crystallization Membrane technology Aqueous-two phase systems Continuous and integrated processes High throughput process development Non-conventional chromatography

DOI related publication

https://doi.org/10.1002/biot.201900274 Final published version

To reference this document use

https://resolver.tudelft.nl/uuid:19060bc0-2457-4383-9231-2f1f16d1fe6b

More Info

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Publication Year

2020

Language

English

Research Group

BT/Bioprocess Engineering

Issue number

8

Volume number

15

Article number

1900274

Downloads counter

252

Abstract

While packed bed chromatography, known as conventional chromatography, has been serving the biopharmaceutical industry for decades as the bioseparation method of choice, alternative approaches are likely to take an increasing leading role in the next few years. The high number of new biological drugs under development, and the need to make biopharmaceuticals widely accessible, has been driving the academia and industry in the quest of anything but conventional chromatography approaches. In this perspective paper, these alternative approaches are discussed in view of current and future challenges in the downstream processing field.