Magnetic resonance thermometry in the target volume versus intraluminal probe thermometry for hyperthermia treatment monitoring
Carolina Carrapiço-Seabra (Erasmus MC)
Spyridon N. Karkavitsas (Ludwig Maximilians University)
Anton Rink (Erasmus MC)
Nahid Montazeri (Erasmus MC)
Henrike Westerveld (Erasmus MC)
Martine Franckena (Erasmus MC)
Margarethus M. Paulides (Eindhoven University of Technology, Erasmus MC)
Gerard C. van Rhoon (TU Delft - RST/Applied Radiation & Isotopes, Erasmus MC)
Sergio Curto (Erasmus MC)
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Abstract
Background and purpose
Hyperthermia, the elevation of target temperature to 39–44 °C, is monitored using temperature probes. However, these provide limited spatial information, sampling only a few discrete locations. Magnetic resonance (MR) thermometry currently offers an option for three-dimensional (3D) temperature monitoring during hyperthermia. This study compares and correlates temperatures measured by intraluminal probes with MR-based temperatures in (1) the anatomical region containing the intraluminal probes and (2) the hyperthermia target volume (HTV), located at a distance from the probes and representing the primary region of clinical interest.
Methods
Thirteen locally advanced cervical cancer (LACC) patients treated with radiotherapy and hyperthermia were included. Hyperthermia was monitored using intraluminal probes and MR thermometry. MR-based temperatures were compared to intraluminal probe temperatures. Repeated measures correlation was applied to correlate probe and MR-based temperatures in the HTV across all data and on a patient-specific basis.
Results
MR-based temperatures at probe locations showed good agreement with probe measurements (median absolute error ≤ 0.7 °C). In the HTV, MR-based temperatures deviated by a median absolute error of 0.5 °C from probe temperatures. Repeated measures correlations (rrm) between MR and probe-based HTV temperatures ranged from 0.74 to 0.79 across all data and 0.64–0.96 on a patient-specific basis.
Conclusions
MR thermometry demonstrated promising performance for retrospective evaluation of temperature distributions in the HTV. While its current reliability for real-time treatment guidance remains limited, our results support further development towards broader clinical implementation in hyperthermia.
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