Patient-reported outcome measures (PROMs) in pancreatic cancer

a systematic review

Review (2020)

Authors

A.D. Maharaj Monash University
Stella Talic Monash University
Peter Evans Monash University
Brett Knowles Peter Maccallum Cancer Centre, Royal Melbourne Hospital, St. Vincent's Hospital and University of Melbourne
Trevor Leong Peter Maccallum Cancer Centre, Monash University, University of Melbourne
Jennifer Philip St. Vincent's Hospital and University of Melbourne, Peter Maccallum Cancer Centre, University of Melbourne, Royal Melbourne Hospital, Victorian Comprehensive Cancer Centre
Marty D. Smith Alfred Health, Cabrini Health
Liane J. Ioannou Monash University
Sue M. Evans Monash University
John R. Zalcberg Monash University
Rachel E. Neale Queensland Institute of Medical Research
David Goldstein University of New South Wales
Neil D. Merrett Western Sydney University
Kate White University of Sydney
Daniel Croagh Monash University, Epworth HealthCare
Charles H.C. Pilgrim Peninsula Health, Alfred Health, Monash University, Cabrini Health, Peninsula Private Hospital
Affiliation
External organisation
More Info
expand_more

Published Date

2020

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Affiliation

External organisation

Abstract

Background: The aim of this systematic review is to examine patient-reported outcome measures (PROMs), their attributes and application in patients with pancreatic cancer (PC). Method: A systematic literature search was undertaken of articles published to June 2018 to identify PROMs applied in primary studies in PC. Characteristics of the included studies and PROMs were described with identified scales grouped into five domains. The psychometric properties of the identified PROMs were further assessed for reliability and validity among patients with PC. Results: From 1688 studies screened, 170 were included. Almost half (48%) were conducted in patients with unresectable PC; the majority of these (68%) were evaluated in randomized controlled trials. Median questionnaire completion rates fell below 10% of the original cohort within 12 months in patients with unresectable PC compared to 75% in patients with resectable PC. Seventy PROMs were identified, 32 measuring unidimensional parameters (e.g. pain) and 35 measuring multidimensional (e.g. quality of life) constructs. Only five (7%) PROMs were disease-specific and 13 (19%) were validated in patients with PC. Fifty scales were grouped into 19 physical, 9 psychological, 6 psychiatric, 9 social and 7 other domains. Conclusion: Three multidimensional PROMs, the: (i) FACT-HEP in unresectable PC; (ii) QLQ-PAN26 (in conjunction with its core QLQ-C30 PROM) in resectable PC; and (iii) MDASI-GI are recommended as instruments to capture quality of life in patients with PC. Summarised scales and psychometric evaluation provide a framework to choose PROMs for scales not captured by the recommended PROMs.