Towards environmentally acceptable synthesis of chiral α-hydroxy ketones via oxidase-lyase cascades
Sandy Schmidt (TU Delft - BT/Biocatalysis)
Tiago P. Almeida (TU Delft - BT/Biocatalysis)
D Rother (Forschungszentrum Jülich)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
The one-pot multistep enzymatic oxidation of aliphatic and benzylic alcohols to the corresponding aldehydes combined with their subsequent carboligation to chiral α-hydroxy ketones has been exemplarily evaluated in terms of being a “green” biocatalytic approach. Besides the potential to start from bio-derived alcohols, this concept avoids the direct use of the reactive aldehyde intermediates, enables addition of high substrate concentrations in one liquid phase while maintaining enzyme activity and enables a simplified product isolation with diminished waste formation.
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