Nociceptive SSEPs induced using multisine frequency modulated pulse trains

An exploratory study in inducing multi-frequency SSEPs

Master thesis (2020)

Authors

M.J.M. Kasting Mechanical Engineering

Contributors

M. Manoochehri Biomechatronics & Human-Machine Control - Mechanical, Maritime and Materials Engineering (supervisor 1)
Boudewijn van den Berg University of Twente (supervisor 1)
F.C.T. van der Helm Biomechatronics & Human-Machine Control - Mechanical, Maritime and Materials Engineering (supervisor 2)
Faculty
Mechanical Engineering
Copyright: © 2020 Mindy Kasting
More Info
expand_more

Published Date

06-05-2020

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Mechanical Engineering

Abstract

Steady state evoked potentials (SSEPs) using multiple frequency inputs are a well-known method to study the underlying dynamics in the visual, auditory and somatosensory system. Multi-frequency SSEPs provide insight into system dynamics such as delay, non-linearities, and frequency response function. Despite extensive research, little is known about the nociceptive system and its dynamics. Previous research showed the possibility to evoke single frequency nociceptive SSEPs using block wave stimulation. In the present study, we explored the feasibility of evoking multi-frequency nociceptive SSEPs using a multisine frequency modulated pulse train. The novel electrical stimulation technique using a frequency pulse train composed of 3, 7 and 13 Hz can stimulate multiple frequencies simultaneously. For the first time, we were able to induce multi-frequency SSEPs indicated by a contralateral maximal signal to noise ratio EEG response for 3 and 7 Hz. The power in 3 and 7 Hz showed significantly higher power compared to all other frequencies up until 40 Hz. The novel stimulation technique offers a unique opportunity to measure multi-frequency SSEPs related to nociceptive processing, allowing better localization of nociceptive signal processing and possible insight into the dynamics of the nociceptive regulation system.

Files

Thesis.pdf
(.pdf | 56.9 Mb)