Investigation and engineering of respiratory energy coupling in yeasts

Doctoral thesis (2022)

Authors

H. Jürgens BT/Industriele Microbiologie - AS
Research Group
BT/Industriele Microbiologie (AS) (TU Delft)
Copyright: © 2022 H. Jürgens
DOI
help_outline
https://doi.org/10.4233/uuid:320d7140-4fad-4ffa-bc9a-50fcc344ed0f
More Info
expand_more

Published Date

2022

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Industriele Microbiologie

Abstract

Microorganisms, enhanced by genetic engineering, are important cell factories for conversion of renewable feedstocks into fuels, chemicals, biomaterials, nutraceuticals and drugs. Microbial synthesis of these products from chemically simple carbon substrates often requires a net input of free energy in the form of ATP, which is typically provided by respiration in aerobic bioprocesses. In such processes, oxidation of a fraction of the substrate with oxygen releases carbon dioxide and water as final products and provides the ATP that is needed for product formation as well as for maintenance requirements and cellular growth...