Halofunctionalization of alkenes by vanadium chloroperoxidase from Curvularia inaequalis
J. Dong (TU Delft - BT/Biocatalysis)
Elena Fernandez Fueyo (TU Delft - BT/Biocatalysis)
Jingbo Li (Aarhus University)
Zheng Guo (Aarhus University)
Rokus Renirie (Universiteit van Amsterdam)
Ron Wever (Universiteit van Amsterdam)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
The vanadium-dependent chloroperoxidase from Curvularia inaequalis is a stable and efficient biocatalyst for the hydroxyhalogenation of a broad range of alkenes into halohydrins. Up to 1 200 000 TON with 69 s−1 TOF were observed for the biocatalyst. A bienzymatic cascade to yield epoxides as reaction products is presented.
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