The extracellular matrix as hallmark of cancer and metastasis

From biomechanics to therapeutic targets

Review (2024)

Authors

J.J.F. Sleeboom Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering , Erasmus MC
Katja Schenke-Layland Eberhard Karls Universität Tübingen
L.J.W. van der Laan Erasmus MC
Antoine A. Khalil University Medical Center Utrecht
Research Group
Biomaterials & Tissue Biomechanics (Mechanical, Maritime and Materials Engineering) (TU Delft)
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Published Date

2024

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Research Group

Biomaterials & Tissue Biomechanics

Abstract

The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a critical role in cancer. Although research often concentrates on the tumor's cellular aspect, attention is growing for the importance of the cancer-associated ECM. Biochemical and physical ECM signals affect tumor formation, invasion, metastasis, and therapy resistance. Examining the tumor microenvironment uncovers intricate ECM dysregulation and interactions with cancer and stromal cells. Anticancer therapies targeting ECM sensors and remodelers, including integrins and matrix metalloproteinases, and ECM-remodeling cells, have seen limited success. This review explores the ECM's role in cancer and discusses potential therapeutic strategies for cell-ECM interactions.