Enzymatic alcoholysis of alkoxymethyl alkanoates

A possible approach for the kinetic resolution of tertiary alcohols

Journal article (1998)

Authors

Maurice C.R. Franssen Wageningen University & Research
Earl Goetheer Wageningen University & Research
Hugo Jongejan Wageningen University & Research
Aede De Groot Wageningen University & Research
Affiliation
External organisation
Lipase Kinetic resolution Esterase Tertiary alcohols
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Published Date

1998

Language

English

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Abstract

The pivaloyloxymethyl and butanoyloxymethyl derivatives of tert-butanol and linalool (1.4) are readily accepted by hydrolases. Linalool derivative 4b is alcoholysed stereoselectively by Candida rugosa lipase (E=9.7).