An evidence-based model to consolidate medication adherence cost estimation
The medication adherence cost estimation framework
Rachelle L. Cutler (University of Technology Sydney)
Naomi Van Der Linden (University of Technology Sydney)
Shalom I.Charlie Benrimoj (University of Sydney)
Fernando Fernandez-Llimos (Universidade de Lisboa)
Victoria Garcia-Cardenas (University of Technology Sydney)
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Abstract
Aim: To develop a standardized framework determining the economic impact of medication nonadherence. Materials & methods: Secondary analysis of existing literature reported cost data, aggregating cost outcome indicators. Weighted-average cost analysis performed, determining the proportional contribution to total cost. Results: Direct costs were reported in 92% of studies and indirect costs in 4% of studies. Three most utilized cost categories were hospital (68%), primary care (18%) and pharmacy costs (72%). Average unadjusted direct costs ranged from $625 to $154,203 contributing to 88% of the total cost; adjusted medical costs ranged from $565 to $56,313 representing 96% of the total cost. Conclusion: The medication adherence cost estimation framework enables the comparison of costing studies, facilitating informed health policy decision-making based on consistent evidence and terminology.