DisQ

Disentangling Quantitative MRI Mapping of the Heart

Conference Paper (2022)
Author(s)

Changchun Yang (TU Delft - ImPhys/Medical Imaging)

Yidong Zhao (TU Delft - ImPhys/Medical Imaging)

Lu Huang (Huazhong University of Science and Technology)

Liming Xia (Huazhong University of Science and Technology)

Q. Tao (TU Delft - ImPhys/Medical Imaging)

Research Group
ImPhys/Medical Imaging
Copyright
© 2022 C. Yang, Y. Zhao, Lu Huang, Liming Xia, Q. Tao
DOI related publication
https://doi.org/10.1007/978-3-031-16446-0_28
More Info
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Publication Year
2022
Language
English
Copyright
© 2022 C. Yang, Y. Zhao, Lu Huang, Liming Xia, Q. Tao
Research Group
ImPhys/Medical Imaging
Bibliographical Note
Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.@en
Pages (from-to)
291-300
ISBN (print)
978-3-031-16445-3
ISBN (electronic)
978-3-031-16446-0
Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Abstract

Quantitative MRI (qMRI) of the heart has become an important clinical tool for examining myocardial tissue properties. Because heart is a moving object, it is usually imaged with electrocardiogram and respiratory gating during acquisition, to “freeze” its motion. In reality, gating is more-often-than-not imperfect given the heart rate variability and nonideal breath-hold. qMRI of the heart, consequently, is characteristic of varying image contrast as well as residual motion, the latter compromising the quality of quantitative mapping. Motion correction is an important step prior to parametric mapping, however, a long-standing difficulty for registering the dynamic sequence is that the contrast across frames varies wildly: depending on the acquisition scheme some frames can have extremely poor contrast, which fails both traditional optimization-based and modern learning-based registration methods. In this work, we propose a novel framework named DisQ, which Disentangles Quantitative mapping sequences into the latent space of contrast and anatomy, fully unsupervised. The disentangled latent spaces serve for the purpose of generating a series of images with identical contrast, which enables easy and accurate registration of all frames. We applied our DisQ method to the modified Look-Locker inversion recovery (MOLLI) sequence, and demonstrated improved performance of T1 mapping. In addition, we showed the possibility of generating a dynamic series of baseline images with exactly the same shape, strictly registered and perfectly “frozen". Our proposed DisQ methodology readily extends to other types of cardiac qMRI such as T2 mapping and perfusion.

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