Extractant selection strategy for solvent-impregnated resins in fermentations

Journal article (2008)

Authors

Corjan Van den Berg TNO

Mark Roelands TNO

Paul Bussmann TNO

Earl Goetheer TNO

Dirk Verdoes TNO

L.A.M. van der Wielen BT/Bioprocess Engineering - , BT/Biotechnologie

Research Group

BT/Bioprocess Engineering () (TU Delft)

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Published Date

2008

Language

English

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Bioprocess Engineering

Abstract

The application of extractants in whole-cell biocatalysis can have a positive impact on industrial fermentations, in terms of productivity, total amount of product produced, and cell growth. When a product is continuously removed from the microorganism surroundings, product inhibition will be diminished. The strategy is exemplified using phenol as the product and the extractant is selected for solvent-impregnated resins, which can prevent emulsification problems that are commonly encountered in in situ extractive recovery of fermentation products. A systematic approach for selection of superior extractants in whole-cell biocatalysis is discussed in this paper. Three criteria are taken into account, namely, extractant toxicity (log P o/w values), product selectivity, and extractant regeneration.