Towards photon radiotherapy treatment planning with high Z nanoparticle radiosensitisation agents
The Relative Biological Effective Dose (RBED) framework
Jeremy M.C. Brown (Queen's University Belfast, University of Wollongong, TU Delft - RST/Medical Physics & Technology)
Gerard G. Hanna (Queen's University Belfast)
Nathanael Lampe (Université d'Auvergne)
Balder Villagomez-Bernabe (Queen's University Belfast)
James R. Nicol (Queen's University Belfast)
Jonathan A. Coulter (Queen's University Belfast)
Fred J. Currell (Queen's University Belfast)
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Abstract
A novel treatment planning framework, the Relative Biological Effective Dose (RBED), for high Z nanoparticle (NP)-enhanced photon radiotherapy is developed and tested in silico for the medical exemplar of neoadjuvant (preoperative) breast cancer MV photon radiotherapy. Two different treatment scenarios, conventional and high Z NP enhanced, were explored with a custom Geant4 application that was developed to emulate the administration of a single 2 Gy fraction as part of a 50 Gy radiotherapy treatment plan. It was illustrated that there was less than a 1% difference in the dose deposition throughout the standard and high Z NP-doped adult female phantom. Application of the RBED framework found that the extent of possible biological response with high Z NP doping was great than expected via the dose deposition alone. It is anticipated that this framework will assist the scientific community in future high Z NP-enhanced in-silico, pre-clinical and clinical trials.
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