Methyltransferases
Functions and Applications
Eman M.M. Abdelraheem (TU Delft - BT/Biocatalysis)
Benjamin Thair (University College London)
Romina Fernández Varela (Universidad Nacional de Quilmes, Bernal and Concet)
Emely Jockmann (Albert-Ludwigs-Universität Freiburg)
Désirée Popadić (Albert-Ludwigs-Universität Freiburg)
Helen C. Hailes (University College London)
John M. Ward (University College London)
P.L. Hagedoorn (TU Delft - BT/Biocatalysis)
U. Hanefeld (TU Delft - BT/Biocatalysis)
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Abstract
In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.
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