Methyltransferases

Functions and Applications

Review (2022)

Authors

E.M.M. Abdelraheem BT/Biocatalysis - AS
Benjamin Thair University College London
Romina Fernández Varela Universidad Nacional de Quilmes, Bernal and Concet
Emely Jockmann Albert-Ludwigs-Universität Freiburg
Désirée Popadić Albert-Ludwigs-Universität Freiburg
Helen C. Hailes University College London
John M. Ward University College London
P.L. Hagedoorn BT/Biocatalysis - AS
U. Hanefeld BT/Biocatalysis - AS
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Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2022 E.M.M. Abdelraheem, Benjamin Thair, Romina Fernández Varela, Emely Jockmann, Désirée Popadić, Helen C. Hailes, John M. Ward, P.L. Hagedoorn, U. Hanefeld, More Authors
DOI
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https://doi.org/10.1002/cbic.202200212
Biocatalysis Enzymes Methyltransferases S-adenosyl-l-methionine
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Published Date

2022

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

In this review the current state-of-the-art of S-adenosylmethionine (SAM)-dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in synthesis are introduced with different supply and regeneration approaches evaluated. The use of SAM analogues are also described. Finally O-, N-, C- and S-MTs, their synthetic applications and potential for compound diversification is given.