A Nonstereoselective Biocatalytic Approach to the Oxidation of Aryl-Ring-Containing Secondary Alcohols

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A Nonstereoselective Biocatalytic Approach to the Oxidation of Aryl-Ring-Containing Secondary Alcohols

Journal Article (2026)

Author(s)

Hebah Abuzenah (King Fahd University of Petroleum and Minerals)

Frank Hollmann (TU Delft - Applied Sciences)

Musa M. Musa (King Fahd University of Petroleum and Minerals)

Research Group

BT/Biocatalysis

Hydrogen peroxide Unspecific peroxygenases Secondary alcohols Nonstereoselective oxidation

DOI related publication

https://doi.org/10.1002/ejoc.70612 Final published version

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https://resolver.tudelft.nl/uuid:4843fdb3-1c8a-4aba-a69e-5d5a2d9523f7

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Publication Year

2026

Language

English

Research Group

BT/Biocatalysis

Journal title

European Journal of Organic Chemistry

Issue number

27

Volume number

29

Article number

e70612

Page Views

32

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Abstract

Oxidation of secondary alcohols to their corresponding ketones is a transformation of enduring interest in synthetic chemistry. We report a biocatalytic method employing unspecific peroxygenase from Agrocybe aegerita (AaeUPO) using hydrogen peroxide as the sole oxidant, to convert racemic aryl-ring-containing secondary alcohols into their corresponding ketones. The enzyme efficiently oxidizes both enantiomers without stereopreference, producing the desired ketones with minimal to no side products. This approach offers a promising alternative to conventional oxidation methods.

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