Cooling crystallization under influence of a strong DC electric field

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Abstract

Polymorphism is the ability of solid material to exist in more than one form or crystal structure. It is especially important for the pharmaceutical industry, where often one particular polymorph is wanted. This research investigated the effect of a strong DC electric field on polymorphic control during cooling crystallization. In principle, solute molecules in solution can be aligned by a sufficiently strong electric field. As a consequence the electric field can be used towards polymorphic control in a crystallization process. Two experimental setups were used to verify this principle.