Efficient and Practical Transfer Hydrogenation of Ketones Catalyzed by a Simple Bidentate Mn−NHC Complex

Journal article (2019)

Authors

R. van Putten ChemE/Inorganic Systems Engineering - AS
Joeri Benschop External organisation
Vincent J. de Munck External organisation
Manuela Weber Freie Universität Berlin
Christian Müller Freie Universität Berlin
G.A. Filonenko ChemE/Inorganic Systems Engineering - AS
E.A. Pidko ChemE/Algemeen , ChemE/Inorganic Systems Engineering - AS
Research Group
ChemE/Inorganic Systems Engineering (AS) (TU Delft)
Copyright: © 2019 R. van Putten, Joeri Benschop, Vincent J. de Munck, Manuela Weber, Christian Müller, G.A. Filonenko, E.A. Pidko
DOI
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https://doi.org/10.1002/cctc.201900882
Manganese Alcohols Ketones N-Heterocyclic Carbene Transfer Hydrogenation
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Published Date

2019

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Inorganic Systems Engineering

Abstract

Catalytic reductions of carbonyl-containing compounds are highly important for the safe, sustainable, and economical production of alcohols. Herein, we report on the efficient transfer hydrogenation of ketones catalyzed by a highly potent Mn(I)−NHC complex. Mn−NHC 1 is practical at metal concentrations as low as 75 ppm, thus approaching loadings more conventionally reserved for noble metal based systems. With these low Mn concentrations, catalyst deactivation is found to be highly temperature dependent and becomes especially prominent at increased reaction temperature. Ultimately, understanding of deactivation pathways could help close the activity/stability-gap with Ru and Ir catalysts towards the practical implementation of sustainable earth-abundant Mn-complexes.