Horse Liver Alcohol Dehydrogenase-Catalyzed Oxidative Lactamization of Amino Alcohols

Journal article (2018)

Authors

Lei Huang Hamburg University of Technology
Giovanni Vallian Sayoga Hamburg University of Technology
F. Hollmann BT/Biocatalysis - AS
S. Kara BT/Biocatalysis - AS , Hamburg University of Technology, Aarhus University
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2018 Lei Huang, Giovanni Vallian Sayoga, F. Hollmann, S. Kara
DOI
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https://doi.org/10.1021/acscatal.8b02355
Enzymatic cascades Cofactor regeneration Oxidoreductases Horse liver alcohol dehydrogenase Lactams
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Published Date

2018

Language

English

Reuse Rights

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Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

A direct synthesis of lactams (5-, 6-, and 7-membered) starting from amino-alcohols in a bienzymatic cascade is reported. Horse liver alcohol dehydrogenase together with the NADH oxidase from Streptococcus mutans were applied for the oxidative lactamization of various amino alcohols. Crucial parameters for the efficiency of this cascade reaction were elucidated. This report represents a direct approach for biocatalytic oxidative lactamization reaction.