Determination of kinetics in batch cooling crystallization processes

A sequential parameter estimation approach

Journal article (2016)

Authors

S.S. Kadam BASF SE
H.J.M. Kramer Intensified Reaction and Separation Systems - Mechanical, Maritime and Materials Engineering
Research Group
Intensified Reaction and Separation Systems (Mechanical, Maritime and Materials Engineering) (TU Delft)
Modeling Agglomeration Kinetics Crystallization Experimental design
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Published Date

2016

Language

English

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Faculty

Mechanical, Maritime and Materials Engineering

Department

Process and Energy

Research Group

Intensified Reaction and Separation Systems

Abstract

A comprehensive methodology to carry out a sequential parameter estimation approach has been developed and validated for the determination of the kinetic parameters of the crystallization of a generic organic compound. The strength of the approach lies in the thorough design of isothermal experiments which facilitate the isolation and/or decoupling of the different crystallization phenomena. This methodology has been applied for the parameter estimation of primary and secondary nucleation, growth and agglomeration kinetics. The resulting crystallization model has been able to reproduce the quantiles d10, d50 and d90 of the volume-based particle size distribution of an independent seeded validation experiment with an error below 10 μm. The deviation in the prediction has been increased in the case of an independent unseeded experiment, although errors below the uncertainty of the measurement have been always obtained. The methodology here proposed is intended to be an efficient strategy for rapid modeling of batch crystallization processes. Â