Double trouble: Structural basis of Guanylate Binding Proteins targeting pathogen membranes
T.I. Kuhm (TU Delft - Applied Sciences)
A.M. Dogterom – Promotor (TU Delft - Applied Sciences)
A. Jakobi – Copromotor (TU Delft - Applied Sciences)
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Abstract
Mammalian cells have acquired a repertoire of defense strategies to deal with intracellular pathogens summarized as cell-autonomous immunity. In this thesis we studied one family of interferon inducible effector proteins involved in this process called guanylate binding proteins (GBPs). GBPs have been shown to combat a broad variety of pathogens including bacteria, viruses and protozoa. Due to their important antimicrobial role we used a structural approach to better understand the underlying oligomerization properties of GBPs, their organization on membranes as well as the functional implication originating from membrane binding...