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Why Argonaute is needed to make microRNA target search fast and reliable

Journal Article (2017)
Author(s)

M. Klein (Kavli institute of nanoscience Delft, TU Delft - BN/Martin Depken Lab)

S.D. Chandradoss (TU Delft - BN/Chirlmin Joo Lab, Kavli institute of nanoscience Delft)

S.M. Depken (TU Delft - BN/Martin Depken Lab, Kavli institute of nanoscience Delft)

C. Joo (TU Delft - BN/Chirlmin Joo Lab, Kavli institute of nanoscience Delft)

Research Group
BN/Martin Depken Lab
Copyright
© 2017 M. Klein, S.D. Chandradoss, S.M. Depken, C. Joo
DOI related publication
https://doi.org/10.1016/j.semcdb.2016.05.017
More Info
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Publication Year
2017
Language
English
Copyright
© 2017 M. Klein, S.D. Chandradoss, S.M. Depken, C. Joo
Research Group
BN/Martin Depken Lab
Volume number
65
Pages (from-to)
20-28
Reuse Rights

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Abstract

MicroRNA (miRNA) interferes with the translation of cognate messenger RNA (mRNA) by finding, preferentially binding, and marking it for degradation. To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex. In this review we use the language of free-energy landscapes to discuss recent single-molecule and high-resolution structural data in the light of theoretical work appropriated from the study of transcription-factor search. We suggest that experimentally observed internal states of the Ago-miRNA search complex may have the explicit biological function of speeding up search while maintaining specificity.