Assessing antimicrobial resistance connectivity across One Health sectors
Liguan Li (The University of Hong Kong, The Education University of Hong Kong)
Bing Li (Tsinghua University)
Xiaole Yin (School of Civil and Environmental Engineering)
Yu Xia (Southern University of Science and Technology )
Yu Yang (Aalborg University)
Xiaoqing Xu (The University of Hong Kong)
Tommy Tsan Yuk Lam (The University of Hong Kong, State Key Laboratory of Emerging Infectious Diseases, Laboratory of Data Discovery for Health)
Heike Schmitt (TU Delft - BT/Environmental Biotechnology, Rijksinstituut voor Volksgezondheid en Milieu (RIVM))
Mark van Loosdrecht (TU Delft - BT/Environmental Biotechnology, Aalborg University)
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Abstract
The first therapeutic use of antimicrobial agents initiated their endless arms race with antimicrobial resistance (AMR). Although the genes encoding antimicrobial resistance are ancient and ubiquitous in various environmental compartments, including aquatic environments, over eight decades of exposure to selective pressure has changed the way antimicrobial resistance genes (ARGs) emerge and transmit among the three One Health sectors (that is, the intersected sectors of humans, animals and the environment). The dissemination of ARGs has been facilitated by the widespread use of antimicrobials, along with direct and secondary pollution pathways. Current global consensus dictates that AMR should be addressed under a One Health framework. AMR National Action Plans have frequently been formulated. However, the capacity for implementation is not ready in most countries, especially in low- and middle-income regions. This is in part due to the substantial challenges in documenting and controlling cross-sector AMR connectivity. Here we describe the past and current status of AMR, emphasizing the contribution of connectivity to global AMR burden. We discuss connectivity at ecological, microbial and genetic levels; propose an approach based on genomics and metagenomics to assess connectivity; and finally advocate for cross-sector studies to better understand AMR connectivity and mitigate dissemination. We believe that such harmonized connectivity studies will facilitate coordinated actions and investments across sectors and regions to scale up AMR management globally.