A photo-enzymatic cascade to transform racemic alcohols into enantiomerically pure amines
Jenő Gacs (Student TU Delft)
W. Zhang (TU Delft - BT/Biocatalysis)
Tanja Knaus (Universiteit van Amsterdam)
Francesco G. Mutti (Universiteit van Amsterdam)
Isabel W.C.E. Arends (TU Delft - BT/Biocatalysis)
Frank Hollmann (TU Delft - BT/Biocatalysis)
More Info
expand_more
Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.
Abstract
The consecutive photooxidation and reductive amination of various alcohols in a cascade reaction were realized by the combination of a photocatalyst and several enzymes. Whereas the photocatalyst (sodium anthraquinone-2-sulfonate) mediated the light-driven, aerobic oxidation of primary and secondary alcohols, the enzymes (various ω-transaminases) catalyzed the enantio-specific reductive amination of the intermediate aldehydes and ketones. The system worked in a one-pot one-step fashion, whereas the productivity was significantly improved by switching to a one-pot two-step procedure. A wide range of aliphatic and aromatic compounds was transformed into the enantiomerically pure corresponding amines via the photo-enzymatic cascade.
help_outline