Biocatalytic synthesis of lactones and lactams

Journal article (2018)

Authors

F. Hollmann BT/Biocatalysis - AS
S Kara Aarhus University
Diederik J. Opperman University of the Free State
Yonghua Wang South China University of Technology
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2018 F. Hollmann, Selin Kara, Diederik J. Opperman, Yonghua Wang
DOI: https://doi.org/10.1002/asia.201801180
Biocatalysis Lactams Baeyer–Villiger oxidation Lactones Oxidative Lactonisation
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Published Date

2018

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Cyclic esters and amides (lactones and lactams) are important active ingredients and polymer building blocks. In recent years, numerous biocatalytic methods for their preparation have been developed including enzymatic and chemoenzymatic Baeyer–Villiger oxidations, oxidative lactonisation of diols, and reductive lactonisation and lactamisation of ketoesters. The current state of the art of these methods is reviewed.