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Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale

Journal Article (2020)
Author(s)

Georg Höfler (TU Delft - BT/Biocatalysis)

Andrada But (TU Delft - BT/Biocatalysis)

Sabry H.H. Younes (TU Delft - BT/Biocatalysis, Sohag University)

Ron Wever (Universiteit van Amsterdam)

Caroline E. Paul (TU Delft - BT/Biocatalysis)

I.W.C.E. Arends (Universiteit Utrecht)

F Hollmann (TU Delft - BT/Biocatalysis)

Research Group
BT/Biocatalysis
Copyright
© 2020 G.T. Höfler, A. But, S.H.H. Younes, Ron Wever, C.E. Paul, I.W.C.E. Arends, F. Hollmann
DOI related publication
https://doi.org/10.1021/acssuschemeng.9b07494
More Info
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Publication Year
2020
Language
English
Copyright
© 2020 G.T. Höfler, A. But, S.H.H. Younes, Ron Wever, C.E. Paul, I.W.C.E. Arends, F. Hollmann
Research Group
BT/Biocatalysis
Issue number
7
Volume number
8
Pages (from-to)
2602-2607
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Abstract

The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.