Chemoenzymatic Halocyclization of 4-Pentenoic Acid at Preparative Scale
Georg T. Höfler (TU Delft - BT/Biocatalysis)
Andrada But (TU Delft - BT/Biocatalysis)
Sabry H.H. Younes (TU Delft - BT/Biocatalysis, Sohag University)
Ron Wever (Universiteit van Amsterdam)
Caroline E. Paul (TU Delft - BT/Biocatalysis)
Isabel W.C.E. Arends (Universiteit Utrecht)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
The scale-up of chemoenzymatic bromolactonization to 100 g scale is presented, together with an identification of current limitations. The preparative-scale reaction also allowed for meaningful mass balances identifying current bottlenecks of the chemoenzymatic reaction.
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