The rates of Cu(ii)-ATCUN complex formation. Why so slow?
Radosław Kotuniak (Polish Academy of Sciences)
Paulina Szczerba (Polish Academy of Sciences)
Dobromiła Sudzik (Polish Academy of Sciences)
MJF Strampraad (TU Delft - BT/Biocatalysis)
Peter Leon Hagedoorn (TU Delft - BT/Biocatalysis)
Wojciech Bal (Polish Academy of Sciences)
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Abstract
We used a series of modified/substituted GGH analogues to investigate the kinetics of Cu(ii) binding to ACTUN peptides. Rules for rate modulation by 1st and 2nd sphere interactions were established, providing crucial insight into elucidation of the reaction mechanism and its contribution to biological copper transport.