Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis
Study design
S. Seada (Erasmus MC)
Anke W. van der Eerden (Erasmus MC)
Agnita J.W. Boon (Erasmus MC)
Juan Antonio Hernández-Tamames (TU Delft - ImPhys/Vos group, Erasmus MC)
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Abstract
Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.
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