Quantitative MRI protocol and decision model for a ‘one stop shop’ early-stage Parkinsonism diagnosis

Study design

Review (2023)

Authors

S. Abo Seada Erasmus MC
Agnita J.W. Boon Erasmus MC
J.A. Hernandez-Tamames Erasmus MC, ImPhys/Vos group - AS
Research Group
ImPhys/Vos group (AS) (TU Delft)
Copyright: © 2023 S. Abo Seada, Anke W. van der Eerden, Agnita J.W. Boon, J.A. Hernandez-Tamames
DOI: https://doi.org/10.1016/j.nicl.2023.103506
More Info
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Published Date

2023

Language

English

Faculty

Applied Sciences

Department

ImPhys/Imaging Physics

Research Group

ImPhys/Vos group

Abstract

Differentiating among early-stage parkinsonisms is a challenge in clinical practice. Quantitative MRI can aid the diagnostic process, but studies with singular MRI techniques have had limited success thus far. Our objective is to develop a multi-modal MRI method for this purpose. In this review we describe existing methods and present a dedicated quantitative MRI protocol, a decision model and a study design to validate our approach ahead of a pilot study. We present example imaging data from patients and a healthy control, which resemble related literature.