Spherical polyelectrolyte nanogels as templates to prepare hollow silica nanocarriers: observation by small angle X-ray scattering and TEM
Haoya Han (East China University of Science and Technology)
Li Li (East China University of Science and Technology)
Yuchuan Tian (East China University of Science and Technology)
Yunwei Wang (East China University of Science and Technology)
Zhishuang Ye (East China University of Science and Technology)
Qingsong Yang (East China University of Science and Technology)
Yiming Wang (East China University of Science and Technology, TU Delft - ChemE/Advanced Soft Matter)
Regine Von Klitzing (Technische Universität Darmstadt)
Xuhong Guo (Shihezi University, East China University of Science and Technology)
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Abstract
Hollow silica nanoparticles were prepared through generating a silica layer in spherical polyelectrolyte nanogels (SPN), which consisted of a solid core of polystyrene (PS) and a shell of crosslinked poly(acrylic acid) (PAA), followed by removing the PS core via solvent dissolution. Small angle X-ray scattering (SAXS) in combination with TEM were employed to observe SPN, silica-polymer composite, and hollow silica nanoparticles. It was confirmed that SAXS is a powerful method to monitor the generation of silica layer in SPN. The density and thickness of generated silica layer in SPN were found to be tunable by controlling the crosslinking density of the templates. The porous structure and pH sensitivity of silica layer allowed the obtained hollow silica to be ideal carriers for controlled drug delivery.
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