Prolonged Ex vivo Preservation

Creating a Normothermic Machine Perfusion Setup

Master thesis (2019)

Authors

I.M.E. Brouwer Mechanical Engineering

Contributors

J. Dankelman Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering (supervisor 1)
T.G. Goos Medical Instruments & Bio-Inspired Technology - Mechanical, Maritime and Materials Engineering (supervisor 2)
I. Apachitei Biomaterials & Tissue Biomechanics - Mechanical, Maritime and Materials Engineering (supervisor 2)
Faculty
Mechanical Engineering
Copyright: © 2019 Max Brouwer
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Published Date

13-02-2019

Language

English

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Faculty

Mechanical Engineering

Abstract

Expanded Criteria Donor (ECD) organs are being used more often in clinical setting. The regenerative ability of the organs might be able to restore the organ to full functionality ex vivo. For long term kidney stabilization, optimization and monitoring an organ incubator is preferable. However, it is unclear which available parts would work best in synergy. A Normothermic Machine Perfusion (NMP) setup and a Mathematical Windkessel Model were created as a first step in a larger project of prolonged preservation of ECD organs. While the current NMP setup was found adequate for academic research, it can only be used for simple studies using water. Several fundamental improvements need to be made before the setup can be used as a fully functioning NMP setup for kidneys. Key improvements would be the addition of a Windkessel and a different cardiac pump.