Femtosecond Laser Fabrication of Microporous Membranes for Biological Applications

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Femtosecond Laser Fabrication of Microporous Membranes for Biological Applications

Journal Article (2022)

Author(s)

Annalisa Volpe (Università degli Studi di Bari Aldo Moro, Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche)

F.M. Conte Capodacqua (Università degli Studi di Bari Aldo Moro)

Valeria Garzarelli (University of Salento, Istituto di nanotecnologia, Consiglio Nazionale delle Ricerche)

Elisabetta Primiceri (Istituto di nanotecnologia, Consiglio Nazionale delle Ricerche)

Maria Serena Chiriacò (Istituto di nanotecnologia, Consiglio Nazionale delle Ricerche)

Caterina Gaudiuso (Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche, Università degli Studi di Bari Aldo Moro)

Francesco Ferrara (Istituto di nanotecnologia, Consiglio Nazionale delle Ricerche)

Antonio Ancona (Università degli Studi di Bari Aldo Moro, Istituto di Fotonica e Nanotecnologie, Consiglio Nazionale delle Ricerche)

Affiliation

External organisation

Membrane Fs-laser Micromachining Laser drilling Cell manipulation

DOI related publication

https://doi.org/10.3390/ mi13091371 Final published version

To reference this document use

https://resolver.tudelft.nl/uuid:73af16ac-1cab-424e-be50-6affa645c473

More Info

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Publication Year

2022

Language

English

Affiliation

External organisation

Journal title

Micromachines

Issue number

1371

Volume number

13

Article number

1371

Downloads counter

175

Abstract

The possibility of fabricating micrometric pore size membranes is gaining great interest in many applications, from studying cell signaling, to filtration. Currently, many technologies are reported to fabricate such microsystems, the choice of which depends strictly on the substrate material and on the final application. Here, we demonstrate the capability with a single femtosecond laser source and experimental setup to fabricate micromembranes both on polymeric and multilayer metallic substrate, without the need for moulds, mask, and complex facilities. In particular, the flexibility of laser drilling was exploited to obtain microfilters with pore size of 8 and 18μm in diameter,on metallic and polymeric substrate, respectively, and controlled distribution. For evaluating the possibility to use such laser-fabricated membranes into biological assay, their biocompatibility has been investigated. To this aim, as a proof of concept, we tested the two materials into viability tests.The culture of mammalian cells on these microfabricated membranes were studied showing their compatibility with cells.