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An alginate-confined peroxygenase-CLEA for styrene epoxidation

Journal Article (2021)
Author(s)

Friederike E.H. Nintzel (Student TU Delft)

Y. Wu (TU Delft - BT/Biocatalysis)

Matteo Planchestainer (ETH Zürich)

Martin Held (ETH Zürich)

Miguel Alcalde (Institute of Catalysis and Petrochemistry, Madrid)

Frank Hollmann (TU Delft - BT/Biocatalysis)

Research Group
BT/Biocatalysis
Copyright
© 2021 Friederike E.H. Nintzel, Y. Wu, Matteo Planchestainer, Martin Held, Miguel Alcalde, F. Hollmann
DOI related publication
https://doi.org/10.1039/d1cc01868j
More Info
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Publication Year
2021
Language
English
Copyright
© 2021 Friederike E.H. Nintzel, Y. Wu, Matteo Planchestainer, Martin Held, Miguel Alcalde, F. Hollmann
Research Group
BT/Biocatalysis
Issue number
47
Volume number
57
Pages (from-to)
5766-5769
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Abstract

Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.