Density reduction effects on the production of [11C]CO2 in Nb-body targets on a medical cyclotron
L. Mues genannt Koers (FH Aachen University of Applied Sciences, TRIUMF)
David Prevost (TRIUMF)
Elisabeth Oehlke (TU Delft - RST/Applied Radiation & Isotopes, FH Aachen University of Applied Sciences)
Cornelia Hoehr (TRIUMF)
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Abstract
Medical isotope production of 11C is commonly performed in gaseous targets. The power deposition of the proton beam during the irradiation decreases the target density due to thermodynamic mixing and can cause an increase of penetration depth and divergence of the proton beam. In order to investigate the difference how the target-body length influences the operation conditions and the production yield, a 12 cm and a 22 cm Nb-target body containing N2/O2 gas were irradiated using a 13 MeV proton cyclotron. It was found that the density reduction has a large influence on the pressure rise during irradiation and the achievable radioactive yield. The saturation activity of [11C]CO2 for the long target (0.083 Ci/μA) is about 10% higher than in the short target geometry (0.075 Ci/μA).