Design of a Minimal Invasive Sentinel Lymph Node Biopsy Device

Actuating a locally expanding adaptable cutting blade

Master Thesis (2024)
Author(s)

A.J. Mommersteeg (TU Delft - Mechanical Engineering)

Contributor(s)

J.J. Van Den Dobbelsteen – Mentor (TU Delft - Medical Instruments & Bio-Inspired Technology)

A.W. Schurink – Graduation committee member (TU Delft - Mechanical Engineering)

Faculty
Mechanical Engineering
More Info
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Publication Year
2024
Language
English
Coordinates
50.91721, 5.91775
Graduation Date
26-06-2024
Awarding Institution
Delft University of Technology
Programme
['Mechanical Engineering | BioMechanical Design']
Sponsors
Erasmus MC
Faculty
Mechanical Engineering
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Abstract

The sentinel lymph node biopsy procedure for melanoma patients can be improved with the use of a minimally invasive sentinel lymph node biopsy device. This thesis shows the early stage designing process of such a device, which can reduce overall tissue damage and opens up possibilities to remove the need for general anaesthesia and therefore the need for an operating room. The design of a device that can locally expand a circular cutting blade is presented. The tests main conclusion is that three rods can indeed be used to actuate variable expansion of such a cutting blade. Subsequently, the blade can be used to cut around different sized target lymph nodes. Furthermore, actuation of this expansion can be achieved through a minimally invasive shaft from outside the patients body. Although further steps of the procedure need to be addressed in order to create a fully functional biopsy device, this thesis shows the potential and feasibility of a locally expanding adaptable cutting blade and provides recommendations for further development steps in the design of a MISLNBD.

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