Hyperpolarised gas filling station for medical imaging using polarised <sup>129</sup>Xe and <sup>3</sup>He

Journal article (2021)

Authors

Wai Tung Lee Australia Nuclear Science and Technology Organization, New South Wales 2234
Gang Zheng Monash University
Cavin L. Talbot University of Queensland
Xin Tong Institute of High Energy Physics Chinese Academy of Science, Spallation Neutron Source Science Center, Dongguan
Tim D'Adam Australia Nuclear Science and Technology Organization, New South Wales 2234
S.R. Parnell RID/TS/Instrumenten groep
Michael de Veer Monash University
Graham Jenkin Monash University and Hudson Institute of Medical Research
Graeme R. Polglase Monash University, Monash University and Hudson Institute of Medical Research
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Research Group
RID/TS/Instrumenten groep
Copyright: © 2021 Wai Tung Lee, Gang Zheng, Cavin L. Talbot, Xin Tong, Tim D'Adam, S.R. Parnell, Michael de Veer, Graham Jenkin, Graeme R. Polglase, More Authors
DOI
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https://doi.org/10.1016/j.mri.2021.02.010
Hyperpolarised Helium-3 Hyperpolarised Xenon-129 Hyperpolariser MRI lung imaging: Spin-exchange optical pumping
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Published Date

2021

Language

English

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Research Group

RID/TS/Instrumenten groep

Abstract

We report the design, construction, and initial tests of a hyperpolariser to produce polarised 129Xe and 3He gas for medical imaging of the lung. The hyperpolariser uses the Spin-Exchange Optical Pumping method to polarise the nuclear spins of the isotopic gas. Batch mode operation was chosen for the design to produce polarised 129Xe and polarised 3He. Two-side pumping, electrical heating and a piston to transfer the polarised gas were some of the implemented techniques that are not commonly used in hyperpolariser designs. We have carried out magnetic resonance imaging experiments demonstrating that the 3He and 129Xe polarisation reached were sufficient for imaging, in particular for in vivo lung imaging using 129Xe. Further improvements to the hyperpolariser have also been discussed.