Microcapsules with a permeable hydrogel shell and an aqueous core continuously produced in a 3D microdevice by all-aqueous microfluidics

Journal article (2017)

Authors

S. Mytnyk ChemE/Advanced Soft Matter - AS
I. Ziemecka ChemE/Advanced Soft Matter - AS
A.G.L. Olive ChemE/Advanced Soft Matter - AS
K. Totlani ChemE/Product and Process Engineering - AS
S. Oldenhof Nederlands Forensisch Instituut (NFI), ChemE/Advanced Soft Matter - AS
M.T. Kreutzer ChemE/Chemical Engineering
V. van Steijn ChemE/Product and Process Engineering - AS
J.H. van Esch ChemE/Advanced Soft Matter - AS
Research Group
ChemE/Advanced Soft Matter (AS) (TU Delft)
Copyright: © 2017 S. Mytnyk, I. Ziemecka, A.G.L. Olive, K. Totlani, S. Oldenhof, M.T. Kreutzer, V. van Steijn, J.H. van Esch, J.W.M. van der Meer
DOI
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https://doi.org/10.1039/c7ra00452d
More Info
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Published Date

2017

Language

English

Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Advanced Soft Matter

Abstract

We report the continuous production of microcapsules composed of an aqueous core and permeable hydrogel shell, made stable by the controlled photo-cross-linking of the shell of an all-aqueous double emulsion. While most previous work on water-based emulsions focused on active droplet formation, here double emulsion droplets were spontaneously generated at a three-dimensional flow-focusing junction through the break-up of a double jet formed by immiscible aqueous solutions of polyethylene glycol and cross-linkable dextrans. The capsules obtained with this lipid-free, organic-solvent-free, and surfactant-free approach displayed excellent stability under a variety of harsh conditions (3