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Microcapsules with a permeable hydrogel shell and an aqueous core continuously produced in a 3D microdevice by all-aqueous microfluidics

Journal Article (2017)
Author(s)

Serhii Mytnyk (TU Delft - ChemE/Advanced Soft Matter)

I Ziemecka (TU Delft - ChemE/Advanced Soft Matter)

A.G.L. Olive (TU Delft - ChemE/Advanced Soft Matter)

Kartik Totlani (TU Delft - ChemE/Product and Process Engineering)

Sander Oldenhof (TU Delft - ChemE/Advanced Soft Matter, Nederlands Forensisch Instituut (NFI))

MT Kreutzer (TU Delft - ChemE/Chemical Engineering)

V. van Steijn (TU Delft - ChemE/Product and Process Engineering)

J.H. van Esch (TU Delft - ChemE/Advanced Soft Matter)

J.W.M. van der Meer

Research Group
ChemE/Advanced Soft Matter
Copyright
© 2017 S. Mytnyk, I. Ziemecka, A.G.L. Olive, K. Totlani, S. Oldenhof, M.T. Kreutzer, V. van Steijn, J.H. van Esch, J.W.M. van der Meer
DOI related publication
https://doi.org/10.1039/c7ra00452d
More Info
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Publication Year
2017
Language
English
Copyright
© 2017 S. Mytnyk, I. Ziemecka, A.G.L. Olive, K. Totlani, S. Oldenhof, M.T. Kreutzer, V. van Steijn, J.H. van Esch, J.W.M. van der Meer
Related content
Research Group
ChemE/Advanced Soft Matter
Issue number
19
Volume number
7
Pages (from-to)
11331-11337
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Abstract

We report the continuous production of microcapsules composed of an aqueous core and permeable hydrogel shell, made stable by the controlled photo-cross-linking of the shell of an all-aqueous double emulsion. While most previous work on water-based emulsions focused on active droplet formation, here double emulsion droplets were spontaneously generated at a three-dimensional flow-focusing junction through the break-up of a double jet formed by immiscible aqueous solutions of polyethylene glycol and cross-linkable dextrans. The capsules obtained with this lipid-free, organic-solvent-free, and surfactant-free approach displayed excellent stability under a variety of harsh conditions (3 <pH <13, high salinity). Drying and rehydration experiments demonstrate the permeability of the shell, which may enable molecular-weight-dependent release and uptake of polar solutes.