Catching DNA with hoops-biophysical approaches to clarify the mechanism of SMC proteins

Review (2017)

Authors

J.M. Eeftens Kavli institute of nanoscience Delft, BN/Cees Dekker Lab - AS
C. Dekker BN/Cees Dekker Lab - AS , Kavli institute of nanoscience Delft
Research Group
BN/Cees Dekker Lab (AS) (TU Delft)
Copyright: © 2017 J.M. Eeftens, C. Dekker
DOI
help_outline
https://doi.org/10.1038/nsmb.3507
More Info
expand_more

Published Date

07-12-2017

Language

English

Reuse Rights

Other than for strictly personal use, it is not permitted to download, forward or distribute the text or part of it, without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license such as Creative Commons.

Faculty

Applied Sciences

Department

BN/Bionanoscience

Research Group

BN/Cees Dekker Lab

Abstract

Structural maintenance of chromosome (SMC) complexes are central regulators of chromosome architecture that are essential in all domains of life. For decades, the structural biology field has been debating how these conserved protein complexes use their intricate ring-like structures to structurally organize DNA. Here, we review the contributions of single-molecule biophysical approaches to resolving the molecular mechanism of SMC protein function.