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A pan-cancer analysis of the microbiome in metastatic cancer

Journal Article (2024)
Author(s)

Thomas W. Battaglia (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

Iris L. Mimpen (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

Joleen J.H. Traets (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

Arne van Hoeck (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

Laurien J. Zeverijn (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

Birgit S. Geurts (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

Gijs F. de Wit (Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

Joris L. Vos (Student TU Delft)

Lodewyk Wessels (TU Delft - Electrical Engineering, Mathematics and Computer Science, Nederlands Kanker Instituut - Antoni van Leeuwenhoek ziekenhuis)

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Research Group
Pattern Recognition and Bioinformatics
DOI related publication
https://doi.org/10.1016/j.cell.2024.03.021 Final published version
More Info
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Publication Year
2024
Language
English
Research Group
Pattern Recognition and Bioinformatics
Issue number
9
Volume number
187
Pages (from-to)
2324-2335.e19
Downloads counter
747
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Abstract

Microbial communities are resident to multiple niches of the human body and are important modulators of the host immune system and responses to anticancer therapies. Recent studies have shown that complex microbial communities are present within primary tumors. To investigate the presence and relevance of the microbiome in metastases, we integrated mapping and assembly-based metagenomics, genomics, transcriptomics, and clinical data of 4,160 metastatic tumor biopsies. We identified organ-specific tropisms of microbes, enrichments of anaerobic bacteria in hypoxic tumors, associations between microbial diversity and tumor-infiltrating neutrophils, and the association of Fusobacterium with resistance to immune checkpoint blockade (ICB) in lung cancer. Furthermore, longitudinal tumor sampling revealed temporal evolution of the microbial communities and identified bacteria depleted upon ICB. Together, we generated a pan-cancer resource of the metastatic tumor microbiome that may contribute to advancing treatment strategies.