Bringing evolutionary cancer therapy to the clinic
a systems approach
A. Soboleva (TU Delft - Transport and Logistics)
I. Grossmann (TU Delft - Safety and Security Science)
Anne Marie C. Dingemans (Erasmus MC)
Jafar Rezaei (TU Delft - Transport and Logistics)
K. Stankova (TU Delft - Transport and Logistics)
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Abstract
Evolutionary cancer therapy (ECT) delays or forestalls the progression of metastatic cancer by adjusting treatment based on individual patient and disease characteristics. Clinical implementation of ECT can improve patient outcomes but faces technical and cultural challenges. To address those, we propose a systems approach incorporating systems modeling, problem structuring, and stakeholder engagement. This approach identifies and addresses barriers to implementation, ensuring the feasibility of ECT in clinical practice and enabling better metastatic cancer care.
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