Resuscitation of very preterm infants with 30% vs. 65% oxygen at birth

Study protocol for a randomized controlled trial

Journal article (2012)
Department
Biomechanical Engineering (Mechanical, Maritime and Materials Engineering) (TU Delft)
Copyright: Licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
DOI: https://doi.org/doi:10.1186/1745-6215-13-65
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Published Date

23-05-2012

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Source:

Trials, 13, 2012

ISSN:

1745-6215

Source:

http://www.trialsjournal.com/content/13/1/65

Faculty

Mechanical, Maritime and Materials Engineering

Department

Biomechanical Engineering

Abstract

Background Resuscitation at birth with 100% oxygen is known to increase the oxidative burden with concomitant deleterious effects. Although fractions of inspired oxygen (FiO2)??88%, Apgar score at 5 min, cumulative O2 exposure, oxidative stress (as determined by glutathione synthesis and oxidative stress markers), retinopathy of prematurity, brain injury and neurodevelopmental outcome at 2 years of age. This study will provide insight into determining the appropriate initial FiO2 to start resuscitation of very preterm infants.