CO2-induced switching between MOF-based bio-mimic slow anion channel and proton pump for medical exhalation detection
Honghao Chen (South China Normal University)
Xiaorui Yue (South China Normal University)
Yifei Fan (South China Normal University)
Bofeng Zheng (South China Normal University)
Sitao Lv (South China Normal University)
Fengnan Wang (The First Affiliated Hospital of Guangzhou Medical University)
Yixun Gao (South China Normal University)
P.J. French (TU Delft - Bio-Electronics)
Yao Wang (South China Normal University)
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Abstract
Inspired by the activation mechanism of slow anion channels 1 (SLAC1) in plants that proton pump reversibly induces plant stomata open for CO2 adsorption, a CO2-switching H+ conduction/HCO3− diffusion dual ion channel (CO2-switching-DIC) was constructed by assembling γ-cyclodextrin-MOF (γ-CD-MOF) and 3,4,9,10-perylenetetracarboxylic acid (PTCA) for CO2 chemiresistive sensing. The obtained CO2 sensor exhibited high response (Rg/R0 = 1.33, 50 ppm) and selectivity, low practical limit of detection (1 ppm) and excellent consistency (94.5%) with a commercial infrared CO2 meter at room temperature. It is indicated that hydrogen bond networks in CO2-switching-DIC will be enlarged with the increasing of carboxylic group’s content on perylene skeleton, thereby modulating proton conductivity at molecular level and furthermore CO2 sensing performance of the composite. The CO2-switching-DIC-based sensor has been utilized to distinguish the exhaled CO2 concentration between lung cancer patients and healthy individuals, illustrating its promising application prospect in non-invasive diagnose.