Photoenzymatic epoxidation of styrenes
Morten M.C.H. Van Schie (TU Delft - BT/Biocatalysis)
Caroline E. Paul (Wageningen University & Research)
Isabel W.C.E. Arends (Universiteit Utrecht)
Frank Hollmann (TU Delft - BT/Biocatalysis)
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Abstract
Two-component-diffusible-flavomonooxygenases are versatile biocatalysts for selective epoxidation-, hydroxylation- or halogenation reactions. Their complicated molecular architecture can be simplified using photochemical regeneration of the catalytically active, reduced FADH
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prosthetic group. In this contribution we provide the proof-of-concept and characterization for the direct regeneration of the styrene monooxygenase from Pseudomonas.
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