Improving the homogeneity of brachytherapy treatment plans generated by BRIGHT using a hotspot registration method based on connected component analysis
J.L.P. Commandeur (TU Delft - Electrical Engineering, Mathematics and Computer Science)
P.A.N. Bosman – Mentor (TU Delft - Algorithmics)
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Abstract
In this thesis BRIGHT, a multi-objective evolutionary algorithm for the creation of treatment plans for high-dose rate brachytherapy for prostate cancer, is extended with a new objective to mitigate the formation of high dose contiguous volumes, i.e. hotspots. Multiple new objectives are tested on their performance to reduce hotspots, while minimally impacting existing objectives.