Improving the homogeneity of brachytherapy treatment plans generated by BRIGHT using a hotspot registration method based on connected component analysis

Master thesis (2021)

Authors

J.L.P. Commandeur Electrical Engineering, Mathematics and Computer Science

Contributors

P.A.N. Bosman Algorithmics - EEMCS (mentor)
Faculty
Electrical Engineering, Mathematics and Computer Science, Electrical Engineering, Mathematics and Computer Science
Copyright: © 2021 Joost Commandeur
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Published Date

05-11-2021

Language

English

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Faculty

Electrical Engineering, Mathematics and Computer Science

Abstract

In this thesis BRIGHT, a multi-objective evolutionary algorithm for the creation of treatment plans for high-dose rate brachytherapy for prostate cancer, is extended with a new objective to mitigate the formation of high dose contiguous volumes, i.e. hotspots. Multiple new objectives are tested on their performance to reduce hotspots, while minimally impacting existing objectives.