Miniaturized therapeutic systems for ultrasound-modulated drug delivery to the central and peripheral nervous system

Review (2024)

Authors

P. Zhu Nanjing University of Aeronautics and Astronautics, ChemE/Product and Process Engineering - AS , The Hong Kong Polytechnic University
I. Simón Grau ChemE/Product and Process Engineering - AS
I. Kokalari ChemE/Product and Process Engineering - AS
Daniel S. Kohane Harvard Medical School
A.Y. Rwei ChemE/Product and Process Engineering - AS
Research Group
ChemE/Product and Process Engineering (AS) (TU Delft)
Copyright: © 2024 P. Zhu, I. Simón Grau, I. Kokalari, Daniel S. Kohane, A.Y. Rwei
DOI
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https://doi.org/10.1016/j.addr.2024.115275
Cavitation Microbubble Wearable device Implantable device Sonochemistry Sonosensitizer Ultrasound transducer
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Published Date

2024

Language

English

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Faculty

Applied Sciences

Department

ChemE/Chemical Engineering

Research Group

ChemE/Product and Process Engineering

Abstract

Ultrasound is a promising technology to address challenges in drug delivery, including limited drug penetration across physiological barriers and ineffective targeting. Here we provide an overview of the significant advances made in recent years in overcoming technical and pharmacological barriers using ultrasound-assisted drug delivery to the central and peripheral nervous system. We commence by exploring the fundamental principles of ultrasound physics and its interaction with tissue. The mechanisms of ultrasonic-enhanced drug delivery are examined, as well as the relevant tissue barriers. We highlight drug transport through such tissue barriers utilizing insonation alone, in combination with ultrasound contrast agents (e.g., microbubbles), and through innovative particulate drug delivery systems. Furthermore, we review advances in systems and devices for providing therapeutic ultrasound, as their practicality and accessibility are crucial for clinical application.