Magnetic resonance fingerprinting for simultaneous renal T1 and T2* mapping in a single breath-hold
Ingo Hermann (University Heidelberg, TU Delft - ImPhys/Quantitative Imaging)
Jorge Chacon-Caldera (University Heidelberg)
Iréne Brumer (University Heidelberg)
Benedikt Rieger (University Heidelberg)
Sebastian Weingärtner (TU Delft - ImPhys/Quantitative Imaging)
Lothar R. Schad (University Heidelberg)
Frank G. Zöllner (University Heidelberg)
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Abstract
Purpose: To evaluate the use of magnetic resonance fingerprinting (MRF) for simultaneous quantification of T1 and T*2 in a single breath-hold in the kidneys. Methods: The proposed kidney MRF sequence was based on MRF echo-planar imaging. Thirty-five measurements per slice and overall 4 slices were measured in 15.4 seconds. Group matching was performed for in-line quantification of T1 and T*2. Images were acquired in a phantom and 8 healthy volunteers in coronal orientation. To evaluate our approach, region of interests were drawn in the kidneys to calculate mean values and standard deviations of the T1 and T*2 times. Precision was calculated across multiple repeated MRF scans. Gaussian filtering is applied on baseline images to improve SNR and match stability. Results: T1 and T*2 times acquired with MRF in the phantom showed good agreement with reference measurements and conventional mapping methods with deviations of less than 5% for T1 and less than 10% for T*2. Baseline images in vivo were free of artifacts and relaxation times yielded good agreement with conventional methods and literature (deviation T1:7 ± 4%, T*2:6±3%). Conclusions: In this feasibility study, the proposed renal MRF sequence resulted in accurate T1 and T*2 quantification in a single breath-hold.
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