Genome-wide Off-target Cleavage Prediction of CRISPR/Cas Nucleases
S.F. de Jong (TU Delft - Applied Sciences)
M. Klein – Mentor (TU Delft - BN/Chirlmin Joo Lab)
S.M. Depken – Mentor (TU Delft - BN/Martin Depken Lab)
Timon Idema – Graduation committee member (TU Delft - BN/Timon Idema Lab)
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Abstract
Predicting off-target cleavage sites for CRISPR/Cas nucleases on the human genome based on biophysical modelling and high-throughput biochemical profiling.