Effect of breathing motion on robustness of proton therapy plans for left-sided breast cancer patients with indication for locoregional irradiation

Journal article (2020)

Authors

L. Klaassen Student, HollandPTC
A. L. Petoukhova Haaglanden Medical Center, HollandPTC
S. J.M. Habraken Erasmus MC, HollandPTC
J. Jacobs HollandPTC
M. G.A. Sattler Erasmus MC, HollandPTC
K. Verhoeven Maastricht UMC
Y. L.B. Klaver HollandPTC
Affiliation
External organisation
Robustness Breast cancer Proton therapy Breathing movement
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Published Date

2020

Language

English

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Abstract

Purpose: To investigate the dosimetric impact of breathing motion on robustly optimized proton therapy treatment plans for left-sided breast cancer patients with an indication for locoregional irradiation. Materials and methods: Clinical Target Volumes (CTVs) (left-sided breast, level 1 to 4 axillary lymph nodes, interpectoral and internal mammary lymph node regions) and organs at risk were delineated on 4 D-CTs of ten female patients. After treatment planning to a prescribed dose of 40.05 Gy(RBE) in 15 fractions on the time-averaged CT, the dose was calculated on all ten phases of the breathing cycle. Robustness to setup (5 mm) and range errors (3%) was evaluated for those ten phases. Correlations were evaluated between the phases of the breathing cycle and the D98% of the CTV and the Dmean of the heart. Results: Correlations coefficients were between −0.12 and 0.29. At the most extreme values of the 28 robustness scenarios, the clinical goals were met for all but two patients. The mean heart dose was 0.41 Gy(RBE) with a standard deviation of 0.31 Gy(RBE) of proton therapy plans. Conclusion: The effect of breathing motion on the robustness of proton therapy treatment plans for this patient group is minor and not of clinical significance. Based on this patient group, a deep-inspiration breath hold seems to be unnecessary to improve robustness for these patients.