Chemoenzymatic epoxidation of alkenes with Candida antarctica lipase B and hydrogen peroxide in deep eutectic solvents

Journal article (2017)

Authors

Pengfei Zhou South China University of Technology
Xuping Wang South China University of Technology
Bo Yang South China University of Technology
F. Hollmann BT/Biocatalysis - AS
Yonghua Wang South China University of Technology
Research Group
BT/Biocatalysis (AS) (TU Delft)
Copyright: © 2017 Pengfei Zhou, Xuping Wang, Bo Yang, F. Hollmann, Yonghua Wang
DOI: https://doi.org/10.1039/c7ra00805h
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Published Date

2017

Language

English

Faculty

Applied Sciences

Department

BT/Biotechnologie

Research Group

BT/Biocatalysis

Abstract

Epoxides are important synthetic intermediates for the synthesis of a broad range of industrial products. This study presents a promising solution to the current limitation of enzyme instability. By using simple deep eutectic solvents such as choline chloride/sorbitol, significant stabilization of the biocatalyst has been achieved leading to more robust reactions while using environmentally more acceptable solvents as compared to ionic liquids.