Chemoenzymatic epoxidation of alkenes with Candida antarctica lipase B and hydrogen peroxide in deep eutectic solvents
Pengfei Zhou (South China University of Technology)
Xuping Wang (South China University of Technology)
Bo Yang (South China University of Technology)
Frank Hollmann (TU Delft - BT/Biocatalysis)
Yonghua Wang (South China University of Technology)
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Abstract
Epoxides are important synthetic intermediates for the synthesis of a broad range of industrial products. This study presents a promising solution to the current limitation of enzyme instability. By using simple deep eutectic solvents such as choline chloride/sorbitol, significant stabilization of the biocatalyst has been achieved leading to more robust reactions while using environmentally more acceptable solvents as compared to ionic liquids.
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