Harnessing a versatile monooxygenase GorA to synthesize N-hydroxy compounds
Caroline E. Paul (TU Delft - Applied Sciences)
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Abstract
In Cell Reports Physical Science, Maier et al. unveil a biocatalytic approach for synthesizing N-hydroxy compounds by integrating the flavin-dependent monooxygenase GorA into an enzymatic cascade with the decarboxylase GorB and a formate dehydrogenase-driven cofactor recycling system. This work showcases GorA's substrate scope and establishes a biocatalytic synthetic route for valuable N-hydroxy compounds.